1. Captain, my captain.
I can't emphasize enough how important it is to choose the right captain in premier league fantasy soccer. Double the points is double the points. This season you want have one of the following players as your captain: Fabregas, Rooney, Drogba, Lampard (Always check that they are in playing condition)
2. Hot players
You'll want players that are on top of their game. Those who can score in every match, and those who are likely to get bonus points, because they are playing so well. Bonus points can collect you many, many extra points in one season of fantasy premier league.
3. Clean sheets
No, not the type you have in your bed. But the ones which will give your defender 4 points more, think about it, it's as if you're striker scored a goal. Get players from teams that know how to defense, that like to win games 3-0 or 4-0
4. Wise Transfers
That means don't lose your points to any extra transfers, as those are almost never worth it. Also remember the rule 2, we want hot players. That means, don't be an optimist, if a player hasn't scored in ten games, chances are he won't score in next game. On the other hand, if a player has scored 3 last games, I bet his closer to score again than your other average player.
To get the most out of a wildcard use it as soon as you realize your team isn't performing as well as you had hoped. Some people will tell you to save the wild until the very last rounds of the fantasy soccer season, but I say don't. The more gameweeks your good choices give you extra points, the more points...well, you get the drift.